Feb 17, · Koilocytotic atypia. Koilocytotic atypia Several sections from these Cx bxs sow a mild superficial early koilocytosis with clear cytoplasm and a hyperchromatic small nucleus with no mitotic activity or loss of polarity The changes are those of superficial koilocytosis with minimal dysplasia. Koilocytosis / koilocytotic atypic: related to expression of viral E4 protein and disruption that this causes in cytoplasmic keratin matrix Nuclear changes are required for diagnosis of koilocytosis since nuclear halos may be cause by glycogen accumulation (Arch Pathol Lab Med ;) Note: perinuclear halos (reactive) can also be prominent in postmenopausal cervix without HPV. Koilocytotic atypia defined by Koss and Durfee () and associated with HPV infection by Meisels and Fortin () has been the most reliable indicative of .
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